Grape seed extract, rich in antioxidants, may aid in weight loss by potentially improving metabolism, reducing fat accumulation, and improving insulin sensitivity. Grape seed and skin extract, as well as grape seed oil, contain catechins, which have been found to have anti-obesity effects. According to a study published in the journal ‘Nutrition Research and Practice’, grape seed extract has beneficial effects and reverses some of the negative effects of a high fat diet. Grape seed extract supplementation decreases body weight.